2015年11月11日星期三

Patients with Chronic Renal Failure Should Increase Essential Amino Acid Intake

Essential amino acid can not be synthetized by our body. We mainly obtain essential amino acid from protein. However, for the patients with chronic Renal Failure, they should limit the protein intake. Therefore, it is very important for them to increase the essential amino acid intake.

Amino acid includes essential amino acid and nonessential amino acid. Nonessential amino acid can be synthetized by our own body so we do not have to obtain them from food. Generally, the content of nonessential amino acid is high in plant food like rice, beans and so on. After the amino acid is metabolized, they will produce urine nitrogen, creatinine and other metabolic wastes. For the patients with Chronic Renal Failure, they should limit the protein intake. Therefore, the essential amino acid in their body decreases. However, the nonessential amino acid increases relatively. The imbalanced proportion between essential amino acid and nonessential acid can cause less protein to be synthetized and more to be broken down. Therefore, the non-protein nitrogen increases. Therefore, if the patients with Chronic Renal Failure can increase the essential amino acid intake and keep a low protein diet at the same time, it not only can increase the protein synthesis in body, but also can correct the imbalanced proportion between essential amino acid and nonessential amino acid.


Meanwhile, essential amino acid therapy along with low protein diet can decrease the phosphorus intake greatly thus lowering blood phosphorus level and correcting the metabolic disturbance of calcium and phosphorus. Histidine and tyrosine are not essential amino acid to the healthy persons. However, for the patients with Chronic Renal Failure, the precursor production of histidine decreases leading to histidine insufficiency. Phenylalanine hydroxylase activity declines so less tyrosine is produced thus leading to tyrosine insufficiency. Therefore, histidine and tyrosine are also essential amino acid and they should increase their supplement.

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