2015年11月6日星期五

Conservative Therapies for Polycystic Kidney Disease (PKD)

Polycystic Kidney Disease (PKD) is caused by abnormal gene. In present medicine area, there is no cure for the disease. However, if they can receive treatment in time, it is possible for them to avoid Renal Failure. The conservative therapies for Polycystic Kidney Disease (PKD) are as follows:

In the early stage of Polycystic Kidney Disease (PKD), the patients do not have abnormal symptoms. Usually, it is inspected in physical exam or check for other diseases. At that time, the doctors just tell their patients there is no treatment for the disease at all. As a result, the cysts will continuously enlarge. When they enlarge to some extent, they will lead to some clinical symptoms like high blood pressure, back pain, urinary infection and so on. Then when going to see a doctor for the above symptoms, they just prescribe them some medicines for them to lowering blood pressure, remitting pain and so on. However, those medicines can not prevent the renal function decline at all.

In severe cases of Polycystic Kidney Disease, surgery often recommended to the patients. However, as there are numerous cysts on kidneys, it is impossible for them to remove them completely. Moreover, after the big ones are removed, the small cysts will enlarge very soon for more available space. Also surgery can bring much trauma to kidneys. After surgery, the renal function has obvious decline.

More than 50% of the patients with Polycystic Kidney Disease (PKD) develop End Stage Renal Failure. At that time, dialysis or Kidney Transplant are necessary for them to preserve their life. As for dialysis, it can only remove the micromolecule substances from blood, but the macromolecular and mild-molecular substances are still remain in blood and cause further damage to body. Also, our kidneys can secrete renin a hormone in regulating blood pressure. However, dialysis can not meet this requirement at all.

In terms of Kidney Transplant, the transplanted kidneys can take over the whole function of the native kidneys. However, as the kidney source is rare many patients may die during their long waiting. In addition, even if Kidney Transplant is successful, they have to depend on immunosuppressive drugs to prevent the severe rejection reaction in the rest of their life. In some cases of rejection reaction and complications after Kidney Transplant, the patients may lose their renal function of transplanted kidneys very soon.


Therefore, for the patients with Polycystic Kidney Disease (PKD), the key to prevent their renal function decline is to block and shrink their enlarged cysts as well as repair their impaired nephrons. In this way, they will be able to avoid Renal Failure.

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