Diabetic Nephropathy is a serious complication of Diabetes. It is one of
common death causes for the patients with Diabetes. In the United States, nearly
4000 patients with Diabetes die of Diabetic Nephropathy and patients with
Diabetic Nephropathy on dialysis covers about 1/4 of the total population.
Therefore, the patients with Diabetes should know how they get Diabetic
Nephropathy so as to take prevention in time.
Diabetes can lead to systemic microangiopathy. As glomeruli responsible for
filtrating blood and excreting excessive fluid and wastes in kidneys are
composed of masses of capillaries, kidneys are very likely to be influenced by
microangiopathy. If the patients have a poor control of their blood pressure,
kidneys will have pathological changes very easily. The glomerular basilar
membrane becomes thick and also hyaline deposits in membrane thus causing the
capillaries’ permeability to increase. The renal microangiopathy can lead to
diffusive or segmental glomerular sclerosis. It is the basic pathogenesis of
Diabetic Nephropathy.
Microangiopathy in Diabetes can cause renal ischemia and anoxia resulting in
the increased blood viscosity. As a result, the pressure in glomerular
capillaries increase and the resistance in arteries and afferent arteriole
become higher. Therefore, the ultrafiltration pressure rises. As the glomerular
capillaries and small arteries are damaged, the patients will have proteinuria,
edema and Renal Failure, high blood pressure and so on.
Diabetic Nephropathy is very common among the patients with more than 10~15
years of Diabetes. However, patients do not know much about this disease so most
of them do not receive treatment until they have a large amount of protein in
urine. In that case, they have missed the best therapeutic opportunity and it is
very difficult to reverse the renal function. Therefore, the patients with
Diabetes, especially those with a long disease history, they should go to do
renal test, urine test and blood test regularly so as to find if they have renal
injury in the first time. If you are or your loved ones are Diabetes sufferers
and want to know more about the treatments and prevention of Diabetic
Nephropathy, please consult us on line or email to kidney-treatment@hotmail.com.