Purpura Nephritis is the secondary kidney disorder caused by allergic purpura. With the disease progression, it will lead to a series of symptoms like edema, high blood pressure, and decline in renal function and so on. If uncontrolled, it will be prone to progress into Renal Failure. Therefore, it is very important for the patients with Purpura Nephritis to receive proper treatment to prevent the disease progression.
In conventional therapies, the common medications for Purpura Nephritis are
immunosuppressive agents and hormones. It can be denied that those medicines
have certain effect in alleviating symptoms. However, they can not reverse the
pathological changes of Purpura Nephritis so they can not prevent Purpura
Nephritis progression fundamentally.
In order to prevent the progression of Purpura Nephritis from its root cause,
it is essential for us to know its pathogenesis.
Immunopathology plays an important role in the occurrence of Purpura
Nephritis. For immune deficiency, when the external antigens like virus,
infections and so on invade into body, the antibodies in body are activated.
However, these antibodies fail to fight against the antigens. As a result, a
large amount of immune complexes IgA, IgG, C3 and so on will deposit in the
mesangial area thus leading to glomerular immune mediated injury. The mesangial
cells’ barrier functions are impaired so they can not prevent the red blood
cells, protein from leaking into urine. Meanwhile, after the mesangial cells are
damaged, they will release a series of inflammatory factors that can aggravate
the mesangial cells injury. This vicious circle can promote the mesangial cells
to synthetize Type 1 and Type 3 collagen leading to accumulation of
extracellular matrix. Afterwards, the glomerulosclerosis occurs and renal
fibrosis process is initiated. Based on the pathogenesis of Purpura Nephritis,
Micro-Chinese Medicine Osmotherapy is suggested to the patients. The therapeutic
mechanism of Micro-Chinese Medicine Osmotherapy in treating Purpura Nephritis is
1. Dilate blood vessels
The immune complexes can cause the functional cells of capillaries can not
get enough blood and oxgen supplement. Dilating blood vessels can improve the
renal blood circulation thus remitting the ischemia and anoxia of the renal
Micro-Chinese Medicine can decrease the infiltration of inflammatory cells
thus preventing the further damage to mesangial cells.
The inflammatory factors in blood can increase the blood viscosity.
Therefore, the microthrombus is very likely to form in glomerular capillaries.
Anti-coagulation can alleviate microthrombus formation.
The inflammatory cells and the microthrombus along with the immune complexes
can accelerate Purpura Nephritis progression. The medicines can degrade these
substances and then discharge them out of body finally. Therefore, it can
prevent the disease progression fundamentally.
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