Serum Creatinine is probably the most widely used measure of evaluating renal function. Creatinine is a non-protein waste product of creatine phosphate metabolism by skeletal muscle tissue. Creatinine production is continuous and is proportional to muscle mass. Some people may find they have a higher creatinine level on the routine test, so what does that mean? Is it severe?
Creatinine is freely filtered and therefore the serum creatinine level
depends on the Glomerular Filtration Rate (GFR). Renal dysfunction diminishes
the ability to filter creatinine and the serum creatinine will rise. The only
important pathological condition that causes a significant increase in the serum
creatinine level is damage to a large number of nephrons. The serum creatinine
level does not rise until at least half of the kidney's nephrons are destroyed
or damaged. A threefold increase is considered to reflect a 75% loss of kidney
Reference for serum creatinine:
· Adult males: 0.8 - 1.4 mg/dl
· Adult females: 0.6 - 1.1 mg/dl
· Children: 0.2 - 1.0 mg/dl
Serum creatinine will differ from country to country, because the machine
used is different.
From the above mentioned, we can see that we should pay attention to serum
creatinine once it becomes higher than the normal range. You should go to
hospital to have a through test, find out the cause, and then take accordingly
measures to treat stop the progress of the kidney damage. Or the damage will
develop from little to more, and the kidney function will decline progressively,
finally leading to kidney failure. In the end stage, there will be no methods or
it will get difficult to control the disease condition.
What stage are you in, and what symptoms do you have? If you want to know
more about serum creatinine, or kidney disease, you can directly send emails to