The reasons why the patients have poor resistence for the infections are as
1, massive of IgG is lost with the urine;2, the lack of B factors lead to the
defect of the immune and opsonic action to the bacterium; 3, when the patients
are malnourished, their nonspecific immune response ability become weaker and
their immune ability is more likely to be impaired; 4, large amount of
transferring and zinc are last with the urine; 5, foval factors, such as pleural
effusion, ascites, skin fracture and severe edema and so on, all are the induces
for the infections.
Once the infections are diagnosed, patients should adopt treatment at
Second, hypercoagulable state and venous thrombosis
For why there is the hypercoagulable for the patients with nephrotic syndrome, this is mainly because the change of the blood coagulation
Besides, the application of antibiotics, hormone and diuretic will increase
the risk of venous thrombosis. When the plasma albumin is less than 2.0g/d1, the
risk of the renal vein thrombosis increases. For the acute cases, the patients
may have the back pain, hematuria, proteinuria, the decline of the renal
function and so on. For the chronic cases, there usually is no symptom, while
the protenuria symptom will aggravate. When the thrombus from fall off, it may
cause the pulmonary embolism.
Some patients may are accompanied with the damage to the renal tubules.
Third, acute renal failure
Acute renal failure is one of the most serious complications of nephrotic
syndrome. The main reasons for this complication are as follows:
1, the change of hemodynamics; 2, edema of the renal mesenchyme; 3, acute
interstitial nephritis caused by medicines; 4, bilateral renal venous
thrombosis; 5, vasoconstriction; 6, rapidly progressive glomerulonephritis; 7,
urinary tract obstruction and so on.
Forth, the decline of renal tubules function
The decline of renal tubule function for nephrotic syndrome more likely
occurs to children. The mechanism of this is believed that the renal tubules
epithelial cells are damaged due to reabsorption of the massive protein in the
urine. The common symptoms are glycosuria, acidaminuria, acidosis and so on.
Fifth, dysbolism of the bone and calcium
Due to the Vit D lost with the urine, it will lead to the dysbolism of the
bone and calcium. Then many patients have the symptoms of hypocalcemia.
Sometimes, the patients may have the symptoms of osteomalacia, osteitis fibrosa
cystic and so on.
Sixth, coronary heart disease
Nephrotic Syndrome patients are easy to get Coronary Heart Disease due to
their Hyperlipemia and high-coagulated blood. It has been improved that
incidence of Myocardial Infarction to Nephrotic Syndrome patients is 8 times
higher than that of normal person. Coronary Heart Disease has become the third
factor causing death to Nephrotic Syndrome patients.
Seventh, disorder of electrolyte and metabolism
Applying Diuretic repeatedly or limiting salt improperly can cause
Hyponatremia. Adrenal Cortical Hormone and Diuretic can cause massive urine,
which can lead to Hypokalemia, if Kalium cannot be supplemented timely.
Besides the most advanced therapies throughout the world, we also have the
specialized therapies of Immunotherapy transplantation and Micro-Chinese