The main symptoms of Nephrotic Syndrome is swelling. Why does swelling appear? Many patients feel confused when they are diagnosed with swelling. They don’t know the reason why they have this disease. In order to have a better treatment of Nephrotic Syndrome swelling, we should understand the reasons for this condition.
(1) Plasma colloid osmotic pressure decreases. Exchange of body liquid in
both inside vessel and outside vessel is regulated by both sides of osmotic
pressure. Osmotic pressure includes crystal osmotic pressure and colloid osmotic
pressure. Crystal osmotic pressure comes from crystal materials (mainly
electrolyte). Because they can get through capillary wall freely, they have less
influence on the exchange of inside vessels and outside vessels. Colloid osmotic
pressure is mainly from proteins (albumin mainly). They can’t get through
capillary wall freely, so they are the main factor of the exchange. When
Nephrotic Syndrome occurs, a large number of plasma proteins get lose from
urine, causing hypoproteinemia, leading to the decrease of plasma colloid
osmotic pressure. When plasma colloid osmotic decreases from normal 3.3 ~ 4kPa
to 0.8~1.1kPa, vascular water move to high permeability of interstitial fluid,
(2) Effective hypovolemia reduces. Relocation of plasma water make effective
hypovolemia get reduced. Therefore, changes in body are as follows. Antidiuretic
hormone increases through capacity receptor, increasing water reabsorbed by
tubular. Secondary aldosteronism is produced through the system of excited
renin—angiotensin—aldosterone, increasing the reabsorption of sodium. The
production of inhibiting natriuretic factors reduces kidney natriuresis.
Therefore, there is water and sodium retention in body, further aggravating
It is obvious that swelling is the earliest signal of Nephropathy Syndrome.
When swelling occurs, patients should see the doctors to check what the reasons
for swelling are and make clear about its development trend. Swelling appears in
many diseases, so patients should analyse illness condition and causes to take
measures as early as possible.
Besides what mentioned above, they will introduce the characteristics of swelling, which are helpful for
patients to judge whether they get Nephrotic Syndrome.
1. Positions of swelling. Swelling can be found in eyelid and face. Later, it
will spread to the whole body gradually.
2. Nature of swelling. Swelling presents to be pitting, which can change with
the change of position. For example, if swelling appears in face in the morning,
we can find it in lower limbs in the afternoon. Severity of swelling degree is
3. Symptoms associated with Nephrotic Syndrome swelling. When swelling
occurs, patients look pale. They don’t want to eat and feel painful in abdomen.
Daily urine output decreases. If the condition increases, they feel dizzy,
abdominal pain and headache.
We hope what mentioned above is helpful. If you want to know more about
Nephrotic Syndrome, you can visit our hospital websites or consult our online
experts. We will do our best to help you. Wish you have a good time!