How to treat lupus nephritis
Many diseases is also ignored by people in the early stage, leading to kidney deterioration, then more and more serious, and ultimately no cure. In recent years, lupus nephritis is more common kidney disease, many patients start is also not attach importance to not pay attention to care, which leads to kidney disease. So, while early vote doctors, otherwise, lead to serious illness, and then regret too late. So, lupus nephritis, how to treat it?
Mild systemic lupus erythematosus (such as only a rash, fever or joint symptoms, etc.) and serological abnormalities, if the urine is normal, renal biopsy showed glomerular normal or mild lesions, as appropriate, non-steroidal anti-inflammatory drugs improve the symptoms of lupus nephritis therapy with glucocorticoids or cytotoxic drugs generally do not need to closely track changes in condition; if the urine is abnormal, renal biopsy shows glomerular focal segmental mesangial proliferation accompanied by section segmental necrosis, crescent formation and focal glomerulosclerosis, with low-dose glucocorticoids (eg, prednisone 20 to 40mg / d), as appropriate, plus cytotoxic drugs or Tripterygium preparations.
Second, the heavy systemic lupus erythematosus (such as high fever, joint pain, weakness and / or lesions involving the serosa quickly, the heart, lungs, liver, blood-forming organs and other organ tissue) with acute nephritic syndrome or rapidly progressive glomerulonephritis Zheng, renal biopsy showed diffuse proliferative glomerulonephritis, or crescentic glomerulonephritis, progressive loss of renal function, the therapy of lupus nephritis should be given to standard hormone therapy and CTX pulse therapy; or methylprednisolone Song Long pulse therapy, daily 1.0g, static 3 to 5 days for a course, 7 to 10 days following a moderate dose of prednisone to maintain, if necessary, can be repeated, generally not more than three courses.
Manifested as asymptomatic proteinuria (urine protein> 2g/24h) are used in the treatment of lupus nephritis drug is a glucocorticoid, as appropriate, plus Tripterygium preparations and prednisone combination with cytotoxic drugs, have a certain effect ; performance for asymptomatic hematuria can be used Tripterygium preparations (conventional-dose or double dose) or CTX treatment; conditional best choice of drugs under the renal pathological types.
Fourth, was the pathological types of nephrotic syndrome patients with lupus nephritis, urine red blood cells few, stable renal function or renal biopsy showed membranous lupus nephritis, lupus nephritis therapy should be preferred to prednisone 0.8 ~~ 1.0mg/kg.d 2 to 4 weeks later when the results are poor, the addition of CTX, if accompanied by renal dysfunction, severe hypertension, renal biopsy showed marked hyperplasia of glomerular pathological type of change occurs, it should be give the standard hormone therapy plus CTX pulse therapy.
Constant of proteinuria without systemic lupus erythematosus performance, or azotemia and renal pathology mainly to chronic degenerative conditions; therapy of lupus nephritis is generally not long-term use of prednisone and cytotoxic drug treatment.
End-stage lupus nephritis with chronic renal failure
Therefore, patients with lupus nephritis, must be treated early with a doctor, pay attention to care. Fight for control the disease, in order to avoid kidney disease, bear unnecessary pain. You'd better have a timely treatment, especially in medical treatment, have a healthy body to a better life.