Five immunological test technologies, IGG, IGA, IGM, complement C3 and complement C4 detection. Changes in immunoglobulin and complement has an important role in the development of kidney disease, detection of immunoglobulin and complement changes in the peripheral blood of patients for the understanding of the immune status, to investigate the pathogenesis, guiding the use of clinical immunomodulatory agents and the prognosis of patients have very important significance.
Changes in serum IGG to reflect the degree of glomerular damage, and provide a reference for clinical treatment; IGA is major immunoglobulin in secretions play an important role in local immunity, immunoglobulin increased protein A can mediate immune and inflammatory response caused by acute nephritis and other diseases. The detection of immunoglobulin contribute to the clinical judgment of the glomerular damage.
Active immune complex kidney disease (such as lupus nephritis, systemic lupus erythematosus nephritis, etc.), C3, C4 levels lower; C3, C4, is also an acute phase proteins in systemic infection, rheumatic fever, skin-muscle inflammation, myocardial infarction, severe trauma, and pregnancy can be increased. Complement the level of detection of treatment has a guiding role, it is a diagnostic indicator of kidney disease prognosis.
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