2014年12月22日星期一

The diagnosis of FSGS

This article is concerning about the diagnosis of FSGS,? If you are interested, please read next paragraph!

The diagnosis of this disease is dependent on renal biopsy diagnosis, as FSGS is focal lesions, segmental, when the biopsy chooses wrong materials, especially not reach binding leather cord tissue can be misdiagnosed. If tubule glomerular lesions and lesions discrepancies, tubular atrophy, interstitial fibrosis prominent: O sizes of glomerular volume not equal, O poor response to glucocorticoid treatment of nephrotic syndrome, or have hypertension, hematuria and renal dysfunction, even if no glomerular sclerosis is, this disease should still consider a repeat biopsy if necessary.

The following points will help diagnosis FSGS:

① Early there hypertension and renal dysfunction and hypertension are more prominent renal dysfunction in adult patients, in particular.

② High incidence of microscopic hematuria. Approximately two thirds of patients are FSGS microscopic hematuria.

③ Most FSGS proteinuria in patients with non-selective (minimal change disease were managed with common selective proteinuria)

④ renal tubular dysfunction, urinary levels of NAG FSGS patients and retinol binding protein and urinary lysozyme rise, low urine osmolality.

⑤ Serum IgG. Significantly lower serum IgG dry water was reduced by more than the amount of leakage IgG.

⑥ Poor response to steroid therapy. some sensitive FSGS patients hormone therapy, hormone treatment resistance in later period.

After the diagnosis of FSGS, the need to exclude the possibility of a variety of secondary FSGS.

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