Creatinine (creatinine, Cr) protucdo muscle is metabolized in the human body. Each 20g muscula metabolism can cause 1mg creatinine. Creatinine main rule out the glomerular filtration body. Serum creatinine is two typical exogenous and endogenous. exogenous creatinine is the meat food product after metabolism. endogenous creatinine is metabolize muscle organization products. When stable food meat consumption, there is no change in muscle metabolism. creatinine can cause stable.
When renal function not good creatinine body seconverte in harmful toxin buildup. Plasma creatinine normarmente upper limit is about 100mol / l. Besides hospitals different test standards are different, but can not exceder120mol / l. In time nephron in the number of ml of plasma endogenous creatinine cleaning is called endogenous creatinine clearance (C cr) .Prueba of endogenous creatinine clearance may reflect glomerular filtration rate and effective canditad estimate nephron, why is proof the quantitative determination of kidney damage. Because this mode of easy operation, less interference factor, no higher sensitivity in each experiment seconverte commonly used in the major clinical renal function.
Density changing serum creatinine determined by the rate of glomerular filtration. When the capacity of low leakage, then the density of creatinine rises. If the amount of serum creatinine greater than normal amount, means being hurt by the kidney, serum creatinine can inform the situation exactly being injured kidney, it is not sensitive target. Because when the rate of glomerular filtration down to third man normal, serum creatinine rises only clearly. So because the capacity of metabolism is very strong, when the kidney is hurt less damage, most people do not feel bad, because when many people feel nausea, vomiting, merearse, your kidneys were seriously wounded, now creatinine rises clearly.
No matter serum creatinine is low or serum creatinine is high, patients have to take seriously. Creatinine is produced metabolized in the muscle body, creatinine body discharge outside kidney. Generally the amount of muscle that is stable, so the amount of creatinine production is stable, the serum creatinine level depends on the amount of creatinine mainly discharging. The compensatory kidney function is very strong, if two kidneys both are normal, it only deploys kidney function, serum creatinine can maintain normal. So when kidneys levels have hurt accounted for more than half, can cause serum creatinine rises. Therefore, serum creatinine may not reflect early and mild low kidney function.
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