Minimal change disease is a kidney disorder that can lead to nephrotic syndrome. Can progress to FSGS?
Minimal change disease and nephrotic syndrome
Each kidney is made of more than one million nephrons, which filter blood and produce urine. In minimal change disease, there is damage to the small blood vessels within the nephrons which blood is filtered to produce urine and waste are eliminated. It owes its name to the fact that the injury to the nephrons are only visible under electron microscope. As small blood vessels deteriorate, they will become bored. As a result, a large amount of protein will pass through nephrons, leading to protein in urine. Heavy protein in urine may lead to nephrotic syndrome with minimal change disease.
Can disease with minimal change nephrotic syndrome become FSGS?
Minimal change disease is a progressive renal disorder. Nephrotic syndrome can significantly accelerate your progression. Can disease with minimal change nephrotic syndrome developed in FSGS? If no treatment is applied, FSGS is the result.
FSGS is a very difficult condition to manage. Is characterized by scarring in glomeruli tissue. "Focal" means that some of the glomeruli have scars, while others appear normal. "Segmental" means that only part of the glomeruli are damaged. If there is heavy protein in urine, FSGS progress very quickly. Some patients may develop ESRD within a few years.
How to prevent disease with minimal changes in FSGS? Minimal change disease is a difficult condition to manage. Some patients may have a referral only after a period of treatment with steroids. If falls frequently, you can accelerate renal function decline significantly.
Immunotherapy is an effective treatment for disease with minimal change nephrotic syndrome. You can check the status of their underlying causes and essentially stop its progression.
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