What are the clinical manifestations of urea nitrogen? Today we see together.
1. Renal dysfunction organic: ⑴ variety of primary glomerulonephritis, pyelonephritis, interstitial nephritis, kidney cancer, polycystic kidney disease due to chronic renal failure. ⑵ When mildly impaired renal function in acute renal failure, BUN may change, but GFR (glomerular filtration rate) was reduced to less than 50%, BUN increase. Determination of serum BUN and therefore can not be used as an early indicator of renal function. But for chronic renal failure, especially in the general level of BUN uremic increased in line with the gravity of: decompensation of renal failure GFR decreased to 50ml / min, serum BUN <9 mmol / L; decompensation of renal failure, blood BUN> renal failure, serum BUN> 20 mmol / L .; 9 mmol / L.
2. Prerenal oliguria: as severe dehydration, massive ascites, heart circulatory failure, hepatorenal syndrome caused by inadequate blood volume, renal hypoperfusion resulting in reduced blood flow oliguria. This elevated BUN, creatinine increased, but not obvious, BUN / Cr (mg / dl)> 10:01, known as prerenal azotemia. Expansion increase by more than the amount of urine, BUN may fall on their own.
3. Excessive intake of protein degradation or acute, such as high fever, gastrointestinal bleeding, extensive burns, severe trauma, and Kang thyroid function, high protein diet, but serum creatinine infectious diseases generally not elevated after major surgery. After the above correction, BUN in the blood may decrease.
Reduced: acute tubular necrosis.
Both serum creatinine and blood urea nitrogen were nitrogen and protein metabolism in normal renal function organic end products, these small molecules of glomerular filtration, which can be used indicator diagnostic screening and glomerular filtration function .When reduced glomerular filtration rate, serum creatinine and urea nitrogen retention in blood and increasing maturity.