Nephrotic syndrome is not a specific condition, but a syndrome with a group of symptoms. Low protein in blood and leg edema are common signs of nephrotic syndrome.
Low blood protein in nephrotic syndrome
Glomeruli with more tiny holes act as filters in the kidneys. Under suitable conditions, small molecular waste products can pass through the holes and then be removed from the body as urine. Proteins are too large to pass through the holes to be retained in the body. However, nephrotic syndrome, glomeruli become impaired and scar. Consequently, the protein will squeeze through the end holes and urine, resulting in low urine protein in nephrotic syndrome.
Leg edema in nephrotic syndrome
Blood Proteins are like sponge. Liquid can be maintained to maintain the blood volume in blood vessels. If the protein level in blood decreases, blood proteins are not sufficient to maintain the fluid in blood vessels. Therefore, the fluid in the blood vessels will be infiltrated subcutaneous tissues. Due to gravity, liquid often builds up in lower parts of the body. Therefore, leg edema occurs in nephrotic syndrome.
Low protein in blood and leg edema in nephrotic syndrome treatment
The underlying cause of leg edema in nephrotic syndrome is low blood protein. To control these conditions fundamentally, patients should have a treatment to increase the level of protein in the blood effectively.
Prednisone is the drug most commonly applied to nephrotic syndrome. Can decrease the permeability of the renal blood vessels. Therefore, filtration of blood proteins decrease. However, you can only alleviate the condition, but can not control the underlying cause. Worse, the long-term use of prednisone can cause many adverse effects.
As protein in urine results from damage to glomeruli, if the damage can be reversed, low protein in blood and leg edema in nephrotic syndrome is controlled primarily. Immunotherapy can help patients reach treatment goals primarily to control nephrotic syndrome.
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