Today, together lead us to understand the clinical manifestations of polycystic kidney disease.
Patients with kidney disease in childhood with normal or slightly larger size and shape, number and size of the cyst gradually increased with age and increased in most cases of kidney volume 40 to 50 years age increased to a considerable extent before the appearance of symptoms. The main manifestations of bilateral renal enlargement, kidney pain, hematuria and hypertension.
1. Kidney enlargement
Progress on both sides of nephropathy asymmetry, size differences at the end of the two kidneys can fill the abdominal cavity, the surface of the fabric has a lot of renal cysts, kidney-shaped irregular, uneven difficult.
2. Pain in the kidneys
Often, low back pressure or dull, no pain, sometimes abdominal pain. The pain may be due to physical activity, walking for a long time, such as sedentary exacerbated after the bed to reduce. Renal hemorrhage, infection also causes sudden movements or severe pain stones.
About half of the patients showed microscopic hematuria may have episodes of gross hematuria, the Department of the cyst wall of blood vessels rupture due. Bleeding for a long time can cause blood clots through the ureteral colic. Often accompanied by white blood cells in proteinuria and hematuria, urinary protein less, generally not more than 1.0 g / day. When significant pyuria kidney infection, hematuria aggravated, low back pain with fever.
Hypertension is a common manifestation of polycystic kidney disease, have not increased serum creatinine before, about half of hypertension, cysts oppression surrounding tissue, activation of the renin - angiotensin - aldosterone related. The last 10 years, Graham PC, and Torre V AB Chapman disease confirmed as normal renal tissue, increased between cysts and cyst epithelial cells adjacent interstitial granules renin and aldosterone secretion. These are closely related to the growth of cysts and hypertension. In other words, there cysts grow faster hypertension, can directly affect the prognosis.
5. Kidney Failure
Individual cases that occur in adolescence renal failure, renal dysfunction and rarely before the age of 40 and 70 years old, about half remain renal function, but the development of renal failure, hypertension shorten largely the process, there are still individual patients 80 years of age renal function can be maintained.
6. Polycystic Liver
Polycystic kidney disease found in middle age, about half of the way in the liver capsule, about 70% after 60 years. Generally believed that their development is slower, and more about polycystic kidney disease 10 years later. Their cysts are formed by the loss of bile duct dilation. Moreover, pancreatic and ovarian cysts, colonic diverticulitis complicated may also occur by a high rate.
Palpable physical examination of one or both kidneys, nodular. When infected with tenderness. 50% of patients with increased waist circumference.
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