Nephrotic Syndrome Causes, Symptoms and Complications

Nephrotic Syndrome, just as its name implied, is a serious disease. As Nephrotic Syndrome patients get more and more, people begin to pay attention to Nephrotic Syndrome.

What is Nephrotic Syndrome? It is characterized by large quantities of urine protein, hypoproteinemia, edema and hyperlipidaemia, which is called “three highs and one low” in clinic. If Nephrotic Syndrome is not cured in time, it can develop into uremia. Large quantities of proteinuria and hypoproteinemia must be possessed in Nephrotic Syndrome diagnosis.

Understand Nephrotic Syndrome firstly.
1. Proteinurie: Normal glomerulus filtration membrane filters plasma protein selectively, which can prevent most of plasma protein being filtered. Once plasma protein enters into glomerulus membrane, it can be filtered out because of small volume.

2. Hypoproteinemia: The main reason why patients have Hypoproteinemia is that albumin in urine drops. But the lost quantity is not completely paralleled with the lost in plasma, which results from the combining of plasma albumin. Plasma value results from the balance of metabolism.

3. Hyperlipidaemia: When people have Nephrotic Syndrome, abnormal blood, fat metabolism and transformations, one or several types of lipid density can be found, including plasma TC and TG level getting higher or plasma HDL level getting lower. When TC, TG and lipoprotein in patients’ plasma get higher than normal value, we can call it Hyperlipidaemia. Both high TC hematic disease and high TG hematic disease belong to Hyperlipidaemia. There is pure high TC hematic, pure high TG hematic and mixed hyperlipemia.

4. Edema: The emergence of swell is positively related with hypoproteinemia. However, exceptions are not rarely seen.

Why does Nephrotic Syndrome occur?
Purpura kidney, which is Nephrotic Syndrome in manifestations, can usually be found in teenagers. Limbs purpura, stomachache, arthralgia are the main manifestations in kidney.

Nephrotic Syndrome is caused by various malignancies, which take Nephrotic Syndrome as the early clinical manifestations. Nephrotic Syndrome can usually occur when people suffer breast cancer, lung cancer, stomach cancer, colon cancer and lymphoid hyperplasia.

Diabetic Nephropathy can usually be found among patients who suffer Diabetes for more than 10 years. Particularly, it can be found in patients who suffer type one diabetes but don’t get satisfactory control.

What are the complications of Nephrotic Syndrome?
Infections: Large quantities of immune globulin drop from urine, which can lead to the decrease of plasma protein and influence the formation of antibody.
Electrolyte and Metabolic Disturbance: Secondary Hyponatremia occurs when patients take diuretic repeatedly or resist salt in a long time. Large quantities of urine drop out by taking cortin and diuretic. Hypokalemia appears if there is no enough potassium.

Formation of Thrombus: Thrombus can occur easily, especially with membranous nephropathy rate at 25% to 40%.

Coronary Disease: Hyperlipidemia and blood high condensation state can usually be found. Therefore, Coronary disease occurs easily.

All of the above that the Causes, Symptoms and Complications of Nephrotic Syndrome. If you want learn more about nephrotic syndrome, you can email to renalhealth@hotmail.com, we will try our best to help you.