What causes high creatinine levels in kidney disease?
A change in kidney function is the most common cause of high creatinine levels in the blood. Our kidneys are composed of approximately one million filters for each kidney, called nephrons. One nephron contains a glomerular-and tubule unit. Most creatinine is normally excreted out along these filtering units, so we can maintain the low blood creatinine levels.
In kidney disease, the renal nephrons are damaged, so the filtrating units fail to expel the creatinine in the blood stream adequately, resulting in elevated creatinine levels. Diabetes and chronic high blood pressure are common causes of diminished kidney function.
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