Anaphylactic purpura nephritis, also known as Henoch-Sch?nlein purpura, is a kind of immunological disease with necrotizing vasculitis as its Fundamental pathological changes. It is featured by skin purpura, hemorrhagic gastroenteritis, arthritis and renal damage on clinical manifestation. The damage on renal are called purpura nephritis, which may occur in any age.
It is common among Children under 10, and the ratio of male and female patients was 1.5-3 1. But to adults, the ratio is equal. As for morbidity, it is generally known that, the older the patients are, the higher of the incidence of renal damage will be, and the more serious the renal lesions level will be. Western medicine holds the view that this disease is a kind of allergic trichodangiitis, so the skin capillo, mesenteric vessel and Glomerulus are affected.
Cause purpura nephritis
The direct cause of Henoch-Schonlein Purpura Nephritis, abbreviated as HSPN, is HSP( Henoch-Schonlein Purpura). Then what′re the causes of HSP? It′s reported many factors have connection with the onset of HSP, but the direct reason has not been confirmed. Nowadays, it′s thought HSP is induced by environmental factors on the base of genetic munity. In the following are the relevant factors.
1. Genetic factor
Italian scientists found that some genetics could promote HSP to take placem, and Japanese scholar reported that the deficiency of alexin C4 gene has someting to do with HSP.
2. Infection of bacteria and virus
About one patient in three has infection history before onset of HSP, the common bacterium is βhemolytic streptococcus, but the definite connection between HSP and hemolytic streptococcus is not proven. Other relevant bateria include staphylococcus aureus, mycobacterium tuberculosis, typhoid bacillus, and pneumococcus etc. The virus infection is common with rubella, varicella, epidemic parotitis, measles, and flu etc.
3.Virus infection
It′s the common inducement of HSP, about one HSP patient in four can find the relevant inducement. It may have connection with the allergic reaction to catabolite during the growth of larva of parasite. Roundworm infection is most common and takes up 3/4 among HSP patients induced by virus infection.
4. Foods and Drugs
Food allergies can cause the patient including the common fish, chicken, crab, milk, duck, etc.; allergy drugs are not the normal use of antibiotics, hormones, antipyretic analgesics, tranquilizers, and vaccines.
5. Other factors
If symptoms of the common cold virus infection, accidental abrasions, insect bites infections, pollen, endocrine disorders, and even psychological factors.
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