2013年10月8日星期二

Classification of lupus nephritis and you suffer from lupus nephritis causes

Lupus nephritis affects almost every tissue or organ in the body. Kidney disease is rarely the first manifestation of Lupus; it may come later in the course of the disease and, by then, it is extremely serious and dominates the clinical picture and often leads to renal failure. The disease is due to the deposition, in the kidney, of anti-DNA antibodies or immune complexes which contain these antibodies. Subsequently, various mediators of immune reactions (complement, coagulation, and/or leukocytes) are activated resulting in inflammation. In this short review I plan to outline only a few aspects of this complex condition.

How does a person get lupus nephritis?
It tends to be a gender-based disorder, with the vast majority of cases involving women. It can have a hereditary or genetic element if a parent was a carrier of the gene for the disease. Viruses, infections and environmental factors can play a role. There are no known preventative measures that will protect someone from developing the disease, according to the National Kidney and Urologic Diseases Information Clearinghouse.
Lupus Nephritis Classification
The World Health Organization (WHO) originally classified lupus nephritis based upon histological characteristics of a renal biopsy. The WHO classification was revised by the International Society of Nephrology and the Renal Pathology Society (ISN/RPS) into six classes (TABLE 1). Patients often progress from one classification to another, and treatments will differ according to the severity and extent of the disease.4
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