Diabetic Nephropathy is a common complication of Diabetes. For patients with Diabetes, if they can not control their blood sugar effectively over time, it can cause a series of pathological changes to renal intrinsic cells. Glomerular basilar membrane thickens, which can lead to the lumina of glomerular blood capillaries to narrow. It can then affect the blood microcirculation thus causing renal ischemia and anoxia thus initiating renal fibrosis process. The renal intrinsic cells have phenotypic transformation and produce massive extracellular matrix to replace the healthy renal cells. As a result, glomeruli suffer from necrosis and sclerosis.
In the conventional therapies, the patients just control their blood sugar
and treat some symptoms such as hematuria, proteinuria and other symptoms caused
by kidney damage. However, those therapies can not prevent kidney damage at all.
Many patients with Diabetic Nephropathy will develop into End Stage Renal
Failure. In order to treat Diabetic Nephropathy, the patients should choose a
therapy that is effective both to their primary Diabetes and the secondary
kidney damage. In many years’ clinical practices, Immunotherapy has showed it
enamors effect in treating Diabetic Nephropathy.
Immunotherapys are a group of undifferentiated original cells with
regenerating and differentiating abilities. Immunotherapys can produce many
nutrient factors, which can promote the regeneration of renal intrinsic cells
and islet cells.
Immunotherapys also differentiate into new renal intrinsic
cells and islet cells to replace the necrotic cells to play their roles.
Therefore, Immunotherapy can improve the patients’ renal function greatly and
decline the insulin dosage and even make patients get rid of insulin.