Hypertensive Nephropathy is the secondary disease of chronic blood pressure.
In recent years, the incidence of End Stage Renal Failure is risking year after
year. According to some researches, approximately 15%~20% of End Stage Renal
Failure is caused by high blood pressure. The renal damage caused by high blood
pressure includes benign and malignant arteriolar nephrosclerosis.
First, clinical pathologic features of Hypertensive Nephropathy
Hypertensive Nephropathy usually occurs within 5~10 years of the onset of
high blood pressure. At beginning, the kidneys just have arteriolar pathological
changes and then renal parenchymal damage.
1. Renal arteriolar pathological changes: In the early stage of renal damage,
the kidneys just have arteriolar and microvascular pathological changes. It
mainly presents arterial hyaline change and thickening of endemysium.
2. Renal parenchymal damage: With the development of renal arteriolar
pathological changes, the kidneys will have glomerular and renal tubular
ischemia damage, which is related to the narrowing of arterial lumen. Under
microscopy, glomerulosclerosis and renal tubular atrophy can be observed.
Second, clinical symptoms
1. Increased urination at night is an early symptom of Hypertensive
Nephropathy, which is caused by the renal tubular damage. The patients usually
have mild to moderate proteinuria and the urine protein is less than 2 grams in
24 hours. In some cases, the patients are also complicated with high blood
sugar, high blood fat and high uric acid.
2. Some patients also have left ventricular hypertrophy, coronary heart
disease, heart failure, cerebral hemorrhage or infarction and so on.
If the patients have a poor control of high blood pressure over time, it will
cause sever renal damage and even Renal Failure. If you still can not control
your blood pressure very well after using a large amount of antihypotensive
medicines and want to get more suggestions on how to control blood pressure,
please email to kidney-treatment@hotmail.com.