Uremia is the advanced stage of all Chronic Kidney Diseases. As kidneys are damaged seriously, the toxins and wastes build up in body, which can damage multiple organs and systems. As a result, the patients often have various kinds of clinical symptoms.
1. Water, electrolyte and acid-base disturbance
Water, electrolyte and acid-base disturbance is an early symptom of Uremia.
If it exceeds the compensatory ability of body, it will threaten life
2. Calcium and phosphorus metabolic disorder and renal bone disease
Blood phosphorus increases, blood calcium declines and multiplication of
calcium and phosphorus is abnormal. Renal bone disease is caused by bone
mineralization and bone metabolic disorder. It can occur in the early stage of
renal insufficiency and dialysis patients.
3. Digestive system diseases
Digestive system diseases are early and common complications of Uremia. In
the early stage, the patients usually have poor appetite, vomit, nausea, ammonia
taste in month and so on. What’s worse, some patients even have bleeding in
digestive tract system.
4. Cardiovascular diseases
Cardiovascular diseases are common and most serious complications of Uremia.
It is the number one death cause for the patients. In the early stage, the
patients do not have clinical symptoms, but imaging shows endarterium and
5. Respiratory system diseases
There are two causes of respiratory system diseases including infection and
6. Renal anemia
Renal anemia is a common complication of Uremia and also is an important
factor in promoting the disease progression. In addition, it is also an
important factor in increasing the incidence of cardiovascular diseases and
Infection is the second death cause of Uremia. It is caused by the physical
defense disorder, declined immunity and so on.
8. Nerve system disease
Nerve system disease is a common complication of Uremia. The patients can be
affected by brain disease, peripheral nerve disease and autonomic nerve
disorder, sleeping disorder and so on. The severity of nerve system disease is
closely related to the severity of Uremia severity.
9. Skin disease
Most of patients with Uremia have skin diseases such as skin itching and dry
As Uremia can cause so many serious complications as the above, it is very
important for patients with Chronic Kidney Disease to receive early treatment so
as to prevent the disease progression in early time.