1. Urea nitrogen is primary final product of protein metabolism, which can be excreted by the kidneys.
2. The liver produces ammonia-which contains nitrogen-after is breaks down
proteins used by the body's cells. The nitrogen combines with other elements
like carbon, hydrogen and oxygen, to form urea. With the bloodstream, the urea
travels from the liver to the kidneys. Healthy kidneys filter urea and other
wastes from blood into the urea.
3. A blood urea nitrogen (BUN) test measures the amount of nitrogen in the
blood that comes from the waste product urea. This test is done to see: 1) if
the kidneys are working normally; 2) if the kidney disease is getting worse; 3)
if the treatment of kidney disease is working; 4) check for severe
4. A normal person’s blood urea nitrogen is 2.9-7.1mmol/L and for these over
60, their blood urea nitrogen level is 2.8-7.8mmol/L.
5. If the BUN is normal, there may be no problem with your organs, but if you
want to check the renal function, GFR is recommend even the BUN is normal.
6. The higher urea nitrogen levels than normal may indicate that your kidneys
are not working properly, or it can be caused due to high protein intake,
inadequate fluid intake or poor circulation.
7. The lower urea nitrogen levels may indicate liver disease or damage, or
8. The kidneys have strong compensatory ability, so the BUN level does not
increase until at least 50% of kidney function is impaired. That is to say, the
kidney filtration units-glomeruli-are damaged.
9. Signs and symptoms associated with high urea levels include fatigue,
nausea, insomnia, dry and/or itchy skin, urine-like body odor and/or breath, and
taste and smell (senses) could be affected.
10. The key point to reduce BUN is to repair the impaired renal functional
cells of glomeruli and recover the kidney function. The most advanced
Immunotherapy can help us achieve this purpose.