Healthy kidneys are responsible to clean the blood by removing extra waster,
metabolic wastes and minerals. They can also produce hormones that keep the
bones strong and the blood healthy. In Renal Failure, the kidneys fail to
function adequately, and harmful wastes build up in the body, causing other
problems.
According to nephrologists in Shijiazhuang Kidney Disease Hospital,
Renal Failure occurs due to immune dysfunction.
More than 95% of kidney diseases are caused by the abnormality of immune
system. Thereby nephropathy arises when there is disorder or abnormality of
immune system. Without being controlled effectively, you may deteriorate into
Renal Failure gradually.
How does immune dysfunction occur?
Each of us is born with the normal immune system, called innate immune
system. It in powerful enough to keep us in a healthy state. Besides, to make
sure the safety of innate immune system, there also exists a back-up system.
Only if the innate immune system fails to function normally, the back-up system
can be activated. These two sets of immune systems work together to protect us
from being attacked by disease. However, immune dysfunction may occur in either
of the following cases:
● The innate immune system releases messages to activate the back-up immune
system continuously, which can make the back-up immune system work endlessly,
thus leading to excess immune response.
● The back-up immune system loses self-restriction ability, which also can
cause the back-up immune system to work endlessly.
How does immune dysfunction cause Renal Failure?
In the kidneys, there exists a specific binding site (also known as epitopes)
on renal intrinsic cells and excellular matrixes (kidney tissues) for the immune
complexes and abnormalities to combine onto.
The endless immune inflammatory response not only can not clear up the
pathological foreign substance out of body, but also damage the normal cells and
tissues in body. The excess immune inflammatory response is termed as
hypertensive reaction.
With more and more intense hypertensive reaction, more and more renal
functional cells and tissues are damaged, leading to Renal Failure
eventually.
Read more: Kidney Failure with Creatinine Level 4.7 How to Treat It