2015年9月14日星期一

IgA Nephropathy: Causes, Symptoms, Treatment

IgA Nephropathy (Berger's disease) is a kidney disorder that occurs when immunoglobulin A (IgA)-a protein that helps that body fight infections-settles in the kidneys. After 10~20 years with IgA Nephropathy, the kidneys will show signs of damage. About 25% percent of adults with this disease develop total Renal Failure, and then dialysis or a kidney transplant is needed.

Causes

IgA can be divided into two kinds: serotype and secretion. Serotype IgA, which accounts for 85% of the total IgA, can be found in serum. While secretion IgA exists in secretion fluid covering the mucosal surface of nose, pharynx, trachea, intestines and bladder, and it can inhibit the attachment of microbes on respiratory epithelium and slow down the propagation of virus. In addition, it acts as a mucosal barrier with antibody activity against certain virus, bacteria and ordinary antigen, and it is the first defense line preventing pathogen entering the body.

When the kidney is stimulated by various inflammations, IgA will excessively deposit at mesangial area and other region, combining with antigen and then produce immune complexes, which can result in pathological damage of renal structure and cause a series of clinical manifestations. That is IgA Nephropathy.

Symptoms

● Cola or tea-colored urine, due to blood in the urine (hematuria)

● Periodic pain in the loins, abdomen, sides or flanks

● Protein in urine

● Fatigue

● High blood pressure

● Swelling (edema) of the hands and feet

● Emotional changes

● Becoming more susceptible to allergies

● Lack of response to cold temperatures (mainly in children)

● Urinary tract infections (UTIs, mainly in young girls)

Treatment

Traditional treatments mainly include high blood pressure medications, dietary restrictions, immunosuppressants, Omega-3 fatty acids, Vitamin E, etc.

Immunotherapy available in Shijiazhuang Kidney Disease Hospital for IgA Nephropathy may consist of:

● Immunosuppressants with little or no side-effect

● Micro-Chinese Medicine Osmotherapy

● Immunotherapy

● Immune clearance: immunosorption, plasmapheresis and blood purification
Features

● No toxin or side effects.

● Efficient prevention of recurrence.

● Significantly improve the rate of IgA Nephropathy cures.


● Good quality of life.

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