Why Patients with Diabetic Nephropathy Have High Creatinine Level

Creatinine level is an important reference in assessing renal function. If it rises above the normal, it proves that the kidneys have been damaged badly. High creatinine level is commonly seen in Diabetic Nephropathy. As high creatinine level is attributable to impaired kidneys, it is essential to know the cause of renal damage in Diabetic Nephropathy.

1. High blood sugar can cause hyperfiltration which can cause increased mesangial matrix, incrassation of glomerular basilar membrane (GBM) and glomerular segmental sclerosis. In addition, high pressure in glomeruli is also an important cause of glomerular sclerosis.

2. High blood sugar can change the structure of glomerular epithelial cells and mesangial cells thus impairing the function of the glomeruli.

3. High blood sugar level can cause glycosylation of proteins in plasm and tissues. The glycosylation end products can improve the permeability of renal capillaries and increased extracellular matrix.
The above three factors can change the structure of glomeruli (filters) in kidneys and make them lose the normal filtration function. As a result, the creatinine will accumulate in blood.

How to treat high creatinine level in Diabetic Nephropathy?
High creatinine level is caused by the reduced renal filtration function duo to necrosis and sclerosis of glomeruli. Therefore, to lower creatinine level, the primary goal is to restore the impaired kidneys and recover normal renal function.

At present, Immunotherapy is known to be the most advanced and effective therapy in restoring impaired tissues and organs. When kidneys are restored very well, they will recover their normal structure and filtration function. As a result, the creatinine will be excreted out of body normally. Finally, the creatinine level will lower gradually.

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