How Does Diabetes Develop into Renal Failure

Diabetes is the most common cause of Renal Failure, accounting for 44% of new cases. However, if the patients can take effective preventive measures, they will be able to avoid developing renal injury. Primarily, it is essential to know how Diabetes develops Renal Failure.

Diabetic Nephropathy is the main microvascular disease in Diabetes. Diabetes can damage the kidney structures in different ways.

1. Glomerular sclerosis
2. Renal arteries sclerosis
3. Pyelonephritis
4. Renal papillae necrosis
Although the pathogenesis of Diabetic Nephropathy is not clear yet, the incidence of Diabetic Nephropathy is mainly attributable to the following factors.
1. Hemodynamic changes
The increasing in glomerular blood flow, glomerular filtration rate (GFR) and pressure in glomeruli can cause ischemia and anoxia in kidney tissues.
2. The barrier of glomeruli is damaged thus resulting in renal injury.
3. Increased synthesis of prostaglandin
4. High blood pressure
These abnormalities can cause incrassation of glomerular basilar membrane and proliferation of mesangial matrix thus resulting in glomerular sclerosis finally.
Therefore, to avoid Renal Failure, it is very important for the patients with Diabetes to receive proper treatment as early as possible. However, in some cases, the insulin injection is not enough to control the disease. So, how to treat the disease effectively? How to prevent diabetes developing into diabetic nephropathy?
In China, Immunotherapy is already being successfully used to treat Diabetes. If you want to know if Immunotherapy suits your disease condition, you can send email to us at renalhealth@hotmail.com.