Lupus Nephritis is a kind of autoimmune disease which clinically represents systemic lupus erythematosus and obvious renal damage. It is a regular diagnosis in clinic now, which mainly diagnoses from kidney structure from the point view of histology. But with the modern medical diagnosis in cytology, it is a disease of lupus glomerulus capillary epithelial cell disease. In our hospital, the standard of diagnosis is diagnosed from kidney structure in cytology.
How can the disease happen? The main factors of the disease are as follows:
lupus cell infects human body and causes the mass production of immune complex
in blood such as C3, IgG, and IgM,etc, which deposits on glomerulus capillary
epithelial cell and leads to immune mediated damage to them. Consequently, the
normal function of glomerulus capillary epithelial cell is also injured. As a
result its function of forming an abundant negative charge protective screen is
Because of the damaged function, protein with negative charge in blood will
enter into urine without trouble and be expelled from body with urine. At the
same time the urine test will display with plus protein. By this pathogenesis,
we can easy deduce that your disease in cytology is a disease of glomerulus
capillary epithelial cell caused by the infection of lupus virus with our latest
diagnosis. The clinical diagnosis of the disease is that it is a related disease
with lupus and the symptoms are a series of clinical diagnosis including the
index of protein and uncomfortable symptoms such as edema.
The main factors of catching the disease is autoimmune defects caused by
chronic virus infection, heredity, hormone and environment factors, which
interacts with each other and leads to the body's immune regulation function
disorder together with many systems damage. All those conditions can cause
immune complex in body to deposit on glomerulus capillary epithelial cell and
mesangium cell, and damage its function of forming an abundant negative charge
screen. As a result, protein with negative charge in blood will enter into urine
and be expelled from body with urine. At this time, urine test will display plus
protein and ever more with renal damage.