2016年3月26日星期六

The Symptoms of Diabetic Nephropathy

The Diabetic Nephropathy always happens after ten years since people got Diabetes. Patients may ignore this disease. So it is important to know the symptoms of Diabetic Nephropathy, which can help patients recognize the disease and then take a timely treatment. What kind of symptoms does Diabetic Nephropathy have?

In the early stage, there is always no symptom and the blood pressure is in normal level or a little higher. When the discharge rate of microalbuminuria is more than 200mcg/min by using radioimmunoassay method, this is called occult kidney disease or early-stage kidney disease. If the hypertension and hyperglycemia can be controlled, the illness condition can get well. But without a good control, the disease may develop to clinical Diabetic Nephropathy. At this time, the symptoms of Diabetic Nephropathy can have the following aspects:

1. Proteinuria.

At the beginning, the increase of glomerular filtration pressure and the charge changing of filtration membrane will lead to the urine only appear microalbuminurias. This kind of urine belongs to selective proteinuria and there is no increase of globulin. This state will last many years. With the increase of filtration hole of glomerular basement membrane, the macromolecular substances will cross and cause nonselective clinical proteinuria. With the continuous development of pathological change, the urine protein will becomes persistent severe proteinuria. If the proteinuria is more than 3g/d, it is the symptoms of bad prognosis. The severity of proteinuria of Diabetic Nephropathy patients always develops continuously until the occurrence of Nephrotic Syndrome.

2. Anemia.

Diabetes patient with obvious azotemia may have mild to moderate anemia. There is no effect by using chalybeate treatment. This kind of anemia is caused by the production obstacle of erythrocyte and it may be associated with the long-time restriction of protein diet and the azotemia.

3. Hypertension. This symptom is commonly seen in Diabetic Nephropathy patients. The severe kidney disease may combine with Hypertension, and Hypertension may also accelerate the process and deterioration of Diabetic Nephropathy. So it is very important to effectively control high blood pressure.

4. Edema. The early-stage of Diabetic Nephropathy patients may don’t have edema generally. A few parts of patients may have slight edema before the index of plasma protein decreasing. The edema will decrease when 24-hour urinary protein is more than 3g. The obvious edema can be seen from the patients with a quick development of Diabetic Nephropathy.

5. Renal Insufficiency. The Diabetic Nephropathy is a kind of persist disease. The Azotemia and Uremia is the final stage of this kidney disease.

6. Other symptoms. The diabetic retinopathy is not the symptom of kidney disease, but it is always accompanying to Diabetic Nephropathy. Some people even think that without diabetic retinopathy, the Diabetic Nephropathy won’t occur.


The symptoms of Diabetic Nephropathy can be concluded the above aspects. Diabetic Nephropathy patients should take test regularly. If patients appear the above one or more symptoms, they should take a treatment timely. Good wishes to you and your family.

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