2015年6月18日星期四

What's the Connection between Chronic Renal Failure and Anemia

Anemia happens when there is a low red blood cell count. Red blood cells are responsible for carrying oxygen to all the cell throughout the body. Cells will use oxygen to change the glucose we get from foods into energy. While, anemia is a common problem with Chronic Renal Failure. Why?

Patients with Chronic Renal Failure develop anemia due to low levels of erythropoietin (EPO) and/or iron in the body.

EPO is an endogenous hormone produce by the healthy kidneys. This hormone tells the bone marrow to produce more red blood cells, so more oxygen can be transported. However, if the damaged kidneys fail to work normally, they make little or no EPO.

Anemia in Chronic Renal Failure can also be caused due to iron deficiency. Iron is a mineral which can be found in high-protein foods. This mineral can help make hemoglobin, the protein in the red blood cell that carries oxygen. Patients are often told to follow a low protein diet, so they may not get enough amounts of iron from the diet.

The amount of red blood cells can also be affected by the accumulation of waste products in the blood. Normally, the kidneys can excrete toxins from the blood, but the damaged kidneys fail to filter as normal. If the body cannot get rid of these wastes, they will build up in the bloodstream.


Anemia often occur early in patients with chronic kidney disease, and the anemia worsens with time, as the disease develops. Every organ of the body can be directly or indirectly affected by this condition. If combines with high blood pressure, left ventricular hypertrophy (LVH) can be causes. In severe cases, death can even be result.

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