Lupus Nephritis is a glomerular disease, which is caused by Systemic Lupus Erythematosus (SLE). Nearly all people with SLE will have kidney damage in varying degrees. Therefore, knowing the clinical symptoms of Lupus Nephritis can help patients receive treatment in early time so as to decline the damage to their kidneys greatly.
1. About 30%~50% of patients with Lupus Nephritis have no symptoms. However,
there is abnormality in their urine routine examination. The urine protein
result is negative or they may have less than 1 gram urine protein per day.
Usually, the patients have microscopic hematuria and red cell casts, but their
renal functions are normal.
2. About 40%~60% of patients have Nephritic Syndrome, which includes two
A: simple Nephritic Syndrome. The patients with this type of Nephritic
Syndrome have a large amount of urine protein, serious edema and
hypoproteinemia. The patients with this kind of Nephritic Syndrome usually have
membranous pathological changes, which progresses very slowly. In 10 years, the
livability of patients is 50%. Usually, the patients have inactive SLE
B: Nephritic Syndrome together with Nephritis Syndrome. The patients with
this kind of symptoms often have hematuria, hypertension, and kidney damage and
also are accompanied with active SLE manifestations. The patients with the above
symptoms belong to diffuse proliferative Lupus Nephritis. If the patients do not
receive effective treatment, most of the patients can develop into Renal Failure
in 2 years.
3. About 35%~50% of patients’ renal damage will develop into Chronic
Nephritis. The patients often have urine protein in varying degrees, red blood
casts and red blood cells in urine, renal damage and even Renal Failure. This
type of patients often has diffuse proliferative pathological changes and its
prognosis is very bad.
4. Some patients with SLE may develop Acute Renal Failure accompanied with
active SLE manifestation. The pathological changes present Crecentic
Glomerulonephritis, diffuse proliferative pathological change.
5. Some patients have renal tubular damage. They may have renal tubular
acidosis, kidney stone and renal calcification.
As Lupus Nephritis has different clinical symptoms, once patients get SLE,
they should watch out for the occurrence of the above symptoms so as to receive
treatment in time and decline their renal damage to the greatest extent