2015年8月26日星期三

What are the Causes of IgA Nephropathy

IgA Nephropathy, or Berger's disease, is the most common cause of glomerulonephritis, responsible for approximately 45% of cases. A peak incidence in the second and third decades of life exists, but people of all ages can be affected.

Immunoglobulin A (IgA) is an antibody that plays a key role in your immune system by attacking invading pathogens. However, in IgA Nephropathy, this antibody lodges in the glomeruli, gradually affecting their filtering ability. Causes of IgA Nephropathy are as below:

1. IgA deposits in the mesangium

Due to immune dysfunction, IgA and other immune complexes collect in the mesangium of the glomeruli, so the glomerular basement membrane is damaged. With an impaired filtration function, protein and red blood cells will be spilt out into urine.

2. Genes

There is a genetic component to IgA Nephropathy, and people in some families and in certain ethnic groups are more prone to get this disorder.

3. Infections

Infections such as HIV infection and bacterial infections are associated with the development of IgA kidney disease.

4. Others

Other conditions or factors that are related to the incidence of IgA Nephropathy include:

* Celiac disease, a condition that damages the lining of the small intestine and prevents it from absorbing parts of food that are important for staying healthy. The damage is due to a reaction to eating gluten, a protein found in most grains.

* Cirrhosis, a condition in which scar tissue replaces normal tissue within the liver.

* Dermatitis herpetiformis, an extremely itchy rash make of bumps and blisters. The rash is chronic, and may continues over a long period of time.


Treatment of IgA Nephropathy varies with different causes of your disease. Our online experts are available to give you the best treatment option according to your personalized condition.

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