Treatment for Diabetic Nephropathy varies with different stages and symptoms of the disease, so it is necessary to have a clear understanding of your own illness condition.
Stage 1: glomerular hyperfiltration stage
Kidney functions are changed in this stage. The kidney increases in size
accompanied with increased glomerular filtration rate. There are no symptoms in
Stage 2: Normal albuminuria stage.
The urinary albumin excretion (UAE) is normal (<20ug/min or < 30mg/24h
). It may increase after intense physical activity and can recover after rest.
The glomerular structure has changed. We can find thicken glomerular basement
membrane and increased mesangium matrix. The GFR is higher than normal
(>150ml/min). Patients have normal or slightly elevated blood pressure.
Stage 3: Early stage of Diabetic Nephropathy
The UAE continues increasing more than 20~200ug/min or 30~300mg/24h. There
are obvious thicken of the glomerular basement membrane and increased mesangium
matrix. In this stage, the blood pressure with rise in a slight degree.
Stage 4: Clinical Nephrotic Syndrome
This stage is characterized with large amount of albuminuria
(UAE>200ug/min) and massive proteinuria (more than 3.5 grams daily). GFR will
decline by 1ml/min every month. Patients also present swelling (edema in the
eyelids, lower limbs or even the whole body) and high blood pressure.
Stage 5: Renal Failure.
The GBM become widely thickened, and glomerular capillary lumens become
progressively narrow and more and more necrotic glomeruli appear. Eventually,
the GFR declines to less than 10ml/min. Symptoms of Renal Failure also include
elevated creatinine and BUN levels, severe high blood pressure, edema, poor
appetite, weakness, felling tired or worn out, nausea or vomiting, trouble
For those who take effective treatment in the early stages, Diabetic
Nephropathy can be reversed. As the latest treatment for diabetic kidney
disease, immunotherapy is available in out hospital. If you need any help, feel
free to talk with our online experts.