2015年3月20日星期五

Berger's Disease and Recurrence of ESRD after Transplant

Kidney transplant is a very suitable alternative for people with Berger's Disease that develop into ESRD. Overall success rates are as good or better than those in other primary glomerular diseases. Unfortunately, the disease recurs in the majority of renal grafts and may sometimes result in failed transplant.
ESRD caused by Berger's Disease
Berger disease tend to progress slowly, and about 50 percent of patients do enter into end-stage renal disease within 25 years. So it is a significant contributor to the incidence of ESRD in many countries. Transplant is the treatment of choice for individuals with progressive renal failure due to IgA Nephropathy.
Recurrence of Berger's Disease after transplantation
The frequency of histologic or clinically significant recurrence of IgAN varies in the reported materials, with the incidence possibly increasing as a function of time from transplantation.
Recurrent deposition of IgA may lead to many manifestations, ranging from an incidentally noted histologic finding to mesangioproliferative glomerulonephritis related to blood and protein in the urine and progressive kidney dysfunction. IgA deposition may appear alone or be concurrent with other problems such as chronic rejection.
In most cases, histologic recurrence, with or without evidence of clinical disease can be seen. Once a study that reviewed biopsies from 29 allografts, histologic recurrence of IgA deposition was found in 17 patients (58%). 3 cases had a normal urine test and normal glomeruli, while 5 cases had hematuria, heavy proteinuria, high blood pressure, and progressive kidney failure due to Berger's Disease alone. The predictor for recurrence was a longer time after transplant (46 versus 15 months in those without recurrence).

Faced with the great challenge of Berger's Disease relapse after renal transplantation, patients always suffer a lot. However, in other cases, patients with ESRD caused by this disease have successfully avoid a transplant with natural treatment to significantly improve the kidney function. It has come true for them to live a fully normal life. If you are interested to know more about this, email us to kidney-treatment@hotmail.com for further contact.

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