What Are the Reasons for Severe Swelling of Diabetic Nephropathy

Diabetic Nephropathy is a complication which will be found 3 year later after the attack of Diabetes. Swelling is the typical external manifestation of Diabetic Nephropathy. Severity of swelling can reflect progress of Diabetic Nephropathy. It is important to find out reasons for swelling and take targeted treatment. In the following content, we will introduce the reasons for swelling.

The main reasons for Diabetic Nephropathy are ischemia and hypoxia. If patients have high blood sugar and blood viscosity for a long time, renal blood flow velocity slows down. When blood flow through glomerular capillary, it will cause a corresponding injury to kidneys. The first damage is glomerular capillary endothelial cells. The increased blood viscosity will make part of blood pour into vascular wall, increasing pressure to endothelial cells and leading to the increase of permeability. The increased permeability can make some substances reveal, such as red blood cells and protein. At the same time, part of water in plasma will permeate into tissue space, paving the way for swelling.

Swelling will appear after ischemia and hypoxia. Human body ignores ischemia and hypoxia and its main reaction is to secrete renin. With the ongoing of ischemia and hypoxia, there will be more renin. Renin---angiotensin promote the secretion of aldosterone. The main function of aldosterone is to promote the reabsorption of sodium by renal tubular distal tubule. However, the increase of aldosterone will increase sodium adsorption, leading to quantities of sodium and water retention. The external manifestation is swelling.

Severe swelling of Diabetic Nephropathy results from metabolic disorders caused by long-term high blood sugar. Patients with Diabetic Nephropathy should take active treatment to avoid severe swelling. If you want to know more about Diabetic Nephropathy and swelling, you can email to renalhealth@hotmail.com.  We will do our best to help you. Wish you have a good time!