What Are the Clinical Manifestations and Stages of Diabetic Kidney Disease

Nowadays, Diabetes is a common disease. Besides its damages to people, it also can cause various complications, among which Diabetic Kidney Disease is a serious one. For this disease, different stages have different symptoms. In order to take effective treatment, it is essential for us to know about the clinical manifestations and stages.

Clinical manifestations
1. Proteinuria (protein in urine)
Proteinuria is the manifestation in the early stage. During the early stage, intermittent proteinuria develops into persistent one. White blood cells and casts can be found through urine microscopy.

2. Swelling
Generally, there is no swelling in the early stage of diabetic kidney disease. For some patients, mild swelling appears after plasma protein lowers. If urine protein is more than 3 grams, swelling will appear. Obvious swelling can be found in patients whose illness conditions deteriorate.

3. High blood pressure
Patients who have protein in urine for a long time have high blood pressure, but it is not serious. High blood pressure can aggravate kidney disease.

4. Uremia
Mild to moderate anemia may appear in patients who have significant azotemia. Anemia means the erythropoietin obstacles, which can’t be treated effectively with chalybeate.

5. Renal dysfunction
There are many changes from proteinuria to renal dysfunction. If Diabetes is controlled well, proteinuria can last for many years without the occurrence of renal dysfunction. If Diabetes is controlled badly, renal insufficiency will aggravate gradually.

Patients should pay much attention to the clinical manifestations and take timely treatment. Besides, it is also for patients to know about the clinical stage in order to take effective treatment further. Here are the clinical stages.

Stage I: This stage is characterized by the increase of glomerular filtration rate (GFR) and kidney size. The initial lesion in this stage is consistent with the high blood sugar levels, but it is reversible. It can recover after being treated with insulin, but not all can turn to normal.

Stage II: Urinary albumin excretion rate is normal but structural changes of glomerulus occur.

Stage III: It is the early stage of diabetic kidney disease. Urinary albumin excretion rate is 20--200μg/ min. Blood pressure rises mildly.

Stage IV: Clinical diabetic kidney disease or dominant diabetic kidney disease appear in this stage. This stage is characterized by macro albuminuria (> 3.5g/d), swelling and high blood pressure. If swelling is very serious, this disease has poor response to the diuretic.

Stage V: This is the stage of end-stage renal failure. Once persistent urine protein appears, this disease develops into clinical diabetic kidney disease. Because of extensive thickening of glomerular basement membrane, capillary cavity stenosis, more glomerular abandoned, progressive decline in kidney filtration function, renal failure occurs finally.

Hope what mentioned above is helpful. Experts warn patients once this disease occurs, it is necessary to take timely treatment in case of the occurrence of renal failure. Here we recommend Micro-Chinese Medicine Osmotherapy form China.