IgA Glomerulonephritis is a common autoimmune kidney disease which affects the glomeruli-the small tubes in the kidneys. An antibody called immunoglobulin A deposits in the glomeruli of the kidneys, creating inflammation and inability to properly filter the wastes from the blood. It occurs most often in young adults age sixteen to thirty-five. How do you develop this illness?
This disease arise from an overactive immune response of the body against
substances and tissues normally present in the body. In other words, the body
actually attacks its own cells. The immune system mistakes some parts of the
body as a pathogen and attacks it.
In cases of both autoimmune diseases and inflammatory diseases, they arise
due to aberrant reactions of the human adaptive or innate immune systems. IgA
Glomerulonephritis is just the result of immune dysfunction.
Human body has two immune systems: innate immunity and adaptive immunity. The
former is the immunity one is born with and is the initial response by the body
to eliminate microbes and prevent infection. Only when it fails to function
well, the latter is activated to help with keeping healthy.
In IgA Glomerulonephritis, immune dysfunction occurs when the innate immune
system continuously send signals to make the adaptive system work, or the
adaptive immune system loses self-control ability and work persistently.
Under this condition of immune disorder, those pathogenic foreign substances
that have entered into the body can not be eliminated in time, and the healthy
renal intrinsic cells and tissues are damaged.
If your kidneys are damaged, they fail to filter extra waste products, fluid,
and restrain useful substances like proteins and red blood cells. Consequently,
you may gradually develop various symptoms of IgA kidney disease, such as
proteinuria, hematuria, and edema, etc.