Nephrotic Syndrome (NS) is an immune disease, wherein the immune system is activated improperly to attack the healthy tissues and organs mistakenly. This is called hypersensitivity. Without good control of the hypersensitivity, inflammation in the kidneys will occur which results in damage of the glomeruli, causing NS. Immune tolerance therapy shows promise for treating this disorder.
What is immune tolerance?
In cases of immune diseases, the immune system will mess up, and it can
mistakenly view a part of our own body as a foreign object and attack the body's
own tissue. In NS, the glomeruli-tiny filtering units of the kidney, are
The goal of this therapy is to stop the mistaken autoimmune response by
reprogramming the immune system so that it will not attack the body's own kidney
intrinsic cells or tissues. By doing so, kidney damage can be stopped
successfully, which lay a good basis for further kidney repair process.
Immune tolerance therapy is the third stage of systemic Immunotherapy. It is
an important composition of this holistic treatment.
Immune tolerance therapy in treating NS
During the process of treating kidney disease like NS, measures as below are
adopted to achieve the goal of immune tolerance.
Firstly, let patient's body accept the fact that the renal inherent cells and
tissues have been damaged.
Secondly, in order to protect renal intrinsic cells from being damaged again
by inflammatory response, we need to take action to block inflammatory response
on a regular basis. According to patient's specific illness condition,
immunosuppressive drugs are used regularly. In this way, we can avoid the
recurrence of immune inflammatory response.
Thirdly, an assessment of the immune reaction in the kidneys is needed and we
will make a long-term plan to monitor the inflammatory response and disease. So,
the accuracy of immune blocking can be ensured.
Immune tolerance therapy is a scientific and normalized treatment method. The
frequent relapse of kidney diseases is just due to the absence of this step.
Therefore, treatments capable of producing tolerance would be remarkably
powerful in treating NS and prevent its relapse.