Nephrotic Syndrome is very common in children, especially in the preschool children. Its morbidity in boys is higher than in girls. It can lead to excessive protein leakage causing a series of complication and aggravating renal function decline. Therefore, it is very important for the parents to have their children treated as early as possible. Meanwhile, in order to decrease the incidence of Childhood Nephrotic Syndrome, it is essential for the parents to know how Childhood Nephrotic Syndrome occurs.
In normal condition, the immune system plays an important role in protecting
our body and keeping us healthy. When microorganisms invade into body, the
antibodies in body are activated to fight against them.
However, in some cases, the immune system is disordered. When the foreign
pathological substances antigens invade into body, the antibodies fail to defeat
them. On the contrary, when antibodies encounter and bind to antigens in the
circulation, they may form very large complexes that have difficulty staying
dissolved in the blood. Afterwards, as there is special combination area for the
immune complexes they will deposit in the glomeruli. When the antigen-antibodies
complexes deposited in the glomeruli, the body responds by mounting an
inflammatory response to remove them. As a result, the inflammation can cause
even more damage and impair the function of the glomeruli leading to Childhood
The conventional therapies for Childhood Nephrotic Syndrome mainly include
hormonetherapy and immunosuppressive agents. After a period of medicine
treatment, most of the patients can have obvious improvement. However, long term
hormonetherapy and immunosuppressive agents use can bring enormous side effects
to the children. They can slow their bone development and affect their fertility
in their further. Therefore, hormonetherapy is not recommended to treat and
prevent the relapse of Childhood Nephrotic Syndrome.
As disordered immune system is the major cause of Child Nephrotic Syndrome,
immunotherapy has showed its dramatic effect in the treatment of Childhood
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