2015年10月31日星期六

How Does Childhood Nephrotic Syndrome Occur

Nephrotic Syndrome is very common in children, especially in the preschool children. Its morbidity in boys is higher than in girls. It can lead to excessive protein leakage causing a series of complication and aggravating renal function decline. Therefore, it is very important for the parents to have their children treated as early as possible. Meanwhile, in order to decrease the incidence of Childhood Nephrotic Syndrome, it is essential for the parents to know how Childhood Nephrotic Syndrome occurs.

In normal condition, the immune system plays an important role in protecting our body and keeping us healthy. When microorganisms invade into body, the antibodies in body are activated to fight against them.

However, in some cases, the immune system is disordered. When the foreign pathological substances antigens invade into body, the antibodies fail to defeat them. On the contrary, when antibodies encounter and bind to antigens in the circulation, they may form very large complexes that have difficulty staying dissolved in the blood. Afterwards, as there is special combination area for the immune complexes they will deposit in the glomeruli. When the antigen-antibodies complexes deposited in the glomeruli, the body responds by mounting an inflammatory response to remove them. As a result, the inflammation can cause even more damage and impair the function of the glomeruli leading to Childhood Nephrotic Syndrome.

The conventional therapies for Childhood Nephrotic Syndrome mainly include hormonetherapy and immunosuppressive agents. After a period of medicine treatment, most of the patients can have obvious improvement. However, long term hormonetherapy and immunosuppressive agents use can bring enormous side effects to the children. They can slow their bone development and affect their fertility in their further. Therefore, hormonetherapy is not recommended to treat and prevent the relapse of Childhood Nephrotic Syndrome.

As disordered immune system is the major cause of Child Nephrotic Syndrome, immunotherapy has showed its dramatic effect in the treatment of Childhood Nephrotic Syndrome.


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