Nephrotic Syndrome (NS) occurs in association with a diverse array of primary
and secondary glomerular disorders. Without effective treatment, patients with
Nephrotic Syndrome may suffer from severe complications, which can even threaten
patients’ life. Therefore, we should take the following Nephrotic Syndrome
complications seriously and adopt prompt treatment accordingly.
● Infections
Constant and prolonged loss of proteins leads to low levels of proteins in
the blood, which in turn lead to lowered resistance, making one prone to various
bacterial and viral infections. Common infections usually happen to respiratory
tract, urinary system, skin, etc.
● High blood pressure (hypertension)
Fluid retention in the body can be caused due to loss low levels of proteins,
thus leading to high blood pressure. High blood pressure can hamper kidney
functions.
● High blood cholesterol and elevated blood triglycerides
If the level of the protein albumin in the blood falls, the liver will make
more albumin. At the same time, the liver releases mire cholesterol and
triglycerides.
● Hypercoagulability or hyper-clotting
With loss of anti-clotting factors like antithrombin Ⅲ and plasminogen, blood
looses its capacity to remain fluid. This can result in formation of abnormal
clots in the blood and other organs such as veins. The clot may migrate to other
parts such as lungs and may lead to pulmonary embolism, which is a severe
condition.
● Acute Renal Failure
Due to massive loss of proteins in Nephrotic Syndrome, there is less plasma
albumin, causing decreased colloid osmotic pressure. Besides, the application of
diuretic and antihypertensive agent can lead to volume insufficiency of
effective blood circulation, which further makes the glomerular filtration rate
decrease, thus resulting in Acute Renal Failure.
● Metabolic disturbance and electrolyte disturbance
Electrolyte disturbances like hyponatremia, hypokalemic, etc can be caused by
limitation of sodium intake and urination promotion. In addition, large amount
loss of proteins can lead to malnutrition, reduced immunity, anemia and so on.
Long-term hyperlipemia can lead to coronary arteriosclerosis and vascular
disease.
If you still have any questions about Nephrotic Syndrome complications,
please consult our online experts.