We all know that an early diagnosis of Diabetic Nephropathy is of great
importance, because it can help us prevent and control the disease so as to
reduce its morbidity and mortality. Besides, it is also helpful to have
knowledge of clinical diagnosis of this disorder. How to diagnose Diabetic
Nephropathy clinically? The following are some detailed introduction.
Firstly, it is available to diagnose Diabetic Nephropathy with a kidney
biopsy. We can detect increased mesangial matrix and thickening of the
glomerular basement membrane in the light microscopic findings.
Immunofluorescence is featured by increased staining of the glomerular and
tubular basement membrane and Bowman's capsule for IgG and albumin in a linear
pattern.
Secondly, the clinical presentation of Diabetic Nephropathy contributes to
the diagnosis. For example, a diagnosis of the disease can be inferred if a
patient had Diabetes for at least 7~10 years, developed diabetic retinopathy,
and had macroscopic proteinuria (albuminuria>300mg/d). However, if the
patient has severe proteinurina but do not show a sufficient period of time
and/or retinopathy, may require renal biopsy. Those patients may suffer from
primary glomerulopathies such as Membranous Nephropathy, or other glomerular
diseases.
Thirdly, early in the course of Diabetic Nephropathy, the serum is normal
despite severe proteinuria (>3g/24h). Therefore, diabetics with elevated
serum creatinine in the absence of macroscopic urine protein may also suggest
possible diagnosis of Diabetic Nephropathy. It should be noticed that this
method is less useful in patients treated with ACE inhibitors or angiotensin II
receptor blockers (ARBs), since both classes of drugs are known to reduce
glomerular proteinuria.
Once diagnosed with Diabetic Nephropathy, you should resort to prompt and
effective treatment. Here we recommend Immunotherapy-the most advanced therapy
for kidney disease. It belongs to a natural treatment without any side effects
to patients. Under this treatment, the damaged kidney function can be restored
so the symptoms of Diabetic Nephropathy will disappear spontaneously. So it is a
good choice for you.