In the past, our learning about the disease of Polycystic Kidney Disease is usually from the histology. Now we need to refresh your learning about Polycystic Kidney Disease.
Through electron microscope and light microscope, we discover the kidney is
constituted by only two parts, one part is renal inherent cells and the other is
inherent extracellular matrix, and we have discovered that renal inherent cells
can be divided into five categories, therefore we call them five categories of
inherent cells. At the same time, we have discovered that all cells possess
extracellular matrix and have different shapes except the inherent cells.
Therefore, we think, in fact, it is the two different substances that
construct the special structure of kidney in different means. And a series of
clinical symptoms caused by abnormal change of kidney function are the results
of changes of normal condition of the two types of substance. And by analyzing
this judging process, we have discovered that this process indeed is a judgment
of the change of kidney function on the basis of cells. And then, on the basis
of cells, we have discovered some regulars of change:
The damage process of kidney function is just the process of necrosis and
decrease of renal inherent cells, the process of the development caused by
hyperplasis of extracellular matrix, and the process of the whole kidney turn
into the accretion of extracellular matrix.
As for the disease of Polycystic Kidney Disease, the mechanism is the
abnormal hyperplasia of kidney tubules epithelial cells is its outstanding
feature. When the kidney tubules epithelial cells turn into cysts epithelial
cells, they begin to have the function of secretion. The liquid they secreted
become more and more but there is no normal approach to eliminate. So with the
increase of age and the accumulation of liquid, the cysts will gradually enlarge
and the cysts pressure will increase, then the cysts will press the surrounding
renal tissues and the tension of cysts wall will increase.
Now we can know the causes and the process of the enlargement of the cysts.
Then on the basis of this, we can adopt more effective therapy to treat
Polycystic Kidney Disease.
What is the effective therapy? The effective therapy should aim at
controlling the secretion of cysts fluid and the "the abnormal hyperplasia of
kidney tubules epithelial cells", thus achieve the goal of contracting the
cysts, controlling the enlargement of cysts and preventing the damage to renal