The etiology of purpura nephritis and effective treatment method

Purpura Nephritis (Henoch-Schonlein Purpura Nephritis) is a secondary disease of Henoch-Schonlein purpura. Henoch-Schonlein purpura is a systemic small-vessel vasculities caused by autoimmune disorder or abnormality. It can affect multiple organs and tissues like skin and connective tissues, scrotum, joints, gastrointestinal tract. When the kidneys are involved, it is called Purpura Nephritis (Henoch-Schonlein Purpura Nephritis).
Henoch-Schonlein Purpura Nephritis Causes
Henoch-Schonlein Purpura Nephritis is autoimmune disease. In normal case, the immune system can protect the body from the foreign pathological substances invading into body. Therefore, the body can keep in a healthy and normal state. However, in some cases, the immunity system is activated improperly. As a result, the complexes of immunoglobulin A (IgA) and complement component 3 (C3) are deposited on arteries, capillaries and venules. Afterwards, these immune complexes will be carried to glomerular mesangial are by blood circulation.
As the kidneys have specific blinding epitopes, the immune complexes will deposit in glomeruli mesangial cells. The body mounts an inflammatory response to remove the immune complexes. Ultimately, the inflammation can cause damage to and impair the function of the glomeruli, leading to Henoch-Schonlein Purpura Nephritis.
The treatment of allergic purpura nephritis
The main treatment of allergic purpura nephritis is immunotherapy, can effectively alleviate the uncomfortable symptoms caused by various because kidney disease. After a period of treatment, one can get an obvious improvement. However, only focus on these two kinds of treatment the symptoms of the disease. Therefore, it can prevent the progress of the disease,
In immunotherapy, the infusion of the healthy stem cells into the patients’ body can repair the damaged renal cells and tissues effectively. Under right condition, stem cells can differentiate into new cells, tissues and organs. In the treatment of Purpura Nephritis, stem cells can differentiate into new renal functional cells and renal tissues to replace the diseased ones to function. Therefore, the renal function will improve and even recover normal.
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