Renal Fibrosis in Chronic Nephritis

Renal fibrosis is a kind of pathological changing process, in which the kidneys are damaged gradually until the kidneys fail completely. Renal fibrosis is an important cause in causing Chronic Nephritis progression.

In Chronic Nephritis, various causes cause renal injury and releasing of inflammatory factors resulting in inflammatory response and enhanced cellar activity. As the renal functional cells get more damage, the cells begin to have phenotypic transformation and ossify and lose function gradually. This is the early stage of renal fibrosis, in which more than half of the renal function still keeps normal so the patients do not present obvious symptoms yet. If the renal fibrosis process is not inhibited effectively, the renal function will keep declining further. When the renal fibrosis approaches to the middle stage, the levels of creatinine, BUN etc will rise obviously. With the progression of renal fibrosis, more and more nephrons lose their normal function. When the residual nephrons are less than 15%, the disease develops into End Stage Renal Failure, namely Uremia. In this stage, nearly all nephrons are ossified. In clinic, the patients will have a series of serious complications like brain disease, heart disease, systemic poisoning symptoms etc.

From the above we can see that if the Chronic Nephritis can not be controlled effectively in its early stage, it will activate the renal fibrosis. Further more, if the renal fibrosis can not be blocked, it will cause the renal function to decline gradually. The key to prevent Renal Failure is to block renal fibrosis.

As the inflammatory response is the primary cause of renal fibrosis, the patients should firstly take relevant treatment to prevent the releasing of the inflammatory factors. In this way, they will be able to prevent Chronic Nephritis from developing into Renal Failure.
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