2016年6月15日星期三

The Increase of Serum Creatinine

The examination of serum creatinine is a main method to check the renal function. When the serum creatinine increases, it will threaten the health of the patients. So why does the serum creatinine increase.

Creatinine is a type of toxin which is secreted by muscle. Usually, creatinine is extracted with the urine, if the creatinine is retented in the human body for a long time, it will lead to the increase of serum creatinine.

According to the resource of creatinine, it can be divided into exogenous and endogenous. The former is the product of meat food metabolized in the body. And the later is the metabolism product of our muscle.


However, the endogeny creatinine is the metabolism products of the muscle. In the muscle of human body, creatine generate the creatinine slowly trough the irreversible non-enzyme dehydration,and then the creatinine is released into the blood and excreted out of the human body with the urine. Therefore, the serum creatinine is closely related to the amount of mules of human body. In most cases, it won’t affected by the diets, high catabolism and other renal outside factors. When the exogenous creatinine is stable, the stable amount of endogenous creatinine is about 20mg/kg per day. The degree of serum creatinine is mainly decided by the glomerulus filtration rate. But the serum creatinine is different from the creatinine clearance rate. The creatinine clearance rate is more sensitive than the serum creatinine. During the early stage of the decline of the renal function (compensatory stage), the creatinine clearance rate decrease, but the serum creatinine is normal. When the glomerulus filtration rate decreases by more than 50 percent, the serum creatinine will increase rapidly. Therefore, the obvious increase of serum creatinine means that the renal function has been seriously damaged. Since the creatinine clearance rate will affected by the glomerulus concentrate function, when the renal concentration function is damaged, the serum creatinine is the most reliable index to reflect the glomerulus function. The normal serum creatinine value of male is 53-106gmol/L, and female is 44.2-97.2gmol/L.

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