The kidneys maintain the blood creatinine in a normal range. Creatinine has been found to be a fairly reliable indicator of kidney function. Elevated creatinine level signifies impaired kidney function or kidney disease.
As the kidneys become impaired for any reason, the creatinine level in the blood will rise due to poor clearance of creatinine by the kidneys. Abnormally high levels of creatinine thus warn of possible malfunction or failure of the kidneys. It is for this reason that standard blood tests routinely check the amount of creatinine in the blood.
Why Does the Serum Creatinine Increase?
1. The most common causes of longstanding (chronic) kidney disease in adults are high blood pressure and diabetes mellitus. Certain drugs can sometimes cause abnormally elevated creatinine levels. Serum creatinine can also transiently increase after ingestion of a large amount of dietary meat.
2. The loss of water in the body due to fever, sweat or less drinking. The pachemia in diuresis period reduce the blood volume in kidney and the increase of serum creatinine may appear at this time.
3. For those patients who have suffered from kidney disease, if the disease reappear, they may present oliguria and even anuric, which can be accompanied by Acute Renal Insufficiency, thus driving the serum creatinine up.
4. If patients with Renal Insufficiency also suffer from infections including colds, pneumonia, intestinal tract infection or urinary tract infection, serum creatinine may show increase within a short period of time.
5.Recent elevations may be more easily treated and reversed.
6. Patients who have suffered from kidney disease before wrongly take some medicines with renal toxicity, which can lead to increased serum creatinine and some cases are irreversible.
7. For Hypertension patients, if the blood pressure is not well controlled, long-term massive proteinuria will appear and the disease may develop silently and finally result in the increase of serum creatinine.
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