As for Polycystic Kidney Disease patients, so many cysts grow in kidney cortex and kidney medulla and most of the patients have a family history of this disease. However, what causes can affect this disease. Actually, many factors, internal or external, can affect the occurrence of this disease. Here, in this article there is a simple list of these main factors.
Ⅰ. Internal factors:
Firstly, gene defect is one of the internal causes of Polycystic Kidney
Disease. This is also the reason why most Polycystic Kidney Disease patients
will have a family history. If there is family member who have this disease, the
other family members should be cautious about this disease.
Secondly, gene mutation: some patients get PKD neither from inheritance. They
get the disease due to gene mutation in embryo forming stage. During this stage,
due to various factors, gene mutation happens, causing Polycystic Kidney
Disease. Though this condition seldom happens, it still has the possibility.
Therefore, some PKD patients may not have hereditary history.
Ⅱ. External factors:
Firstly, infections can cause abnormal change to body environment, which is
beneficial to induce cystic gene mutation. Besides, infections on any part of
body can get into kidney with blood, affecting cysts growth. If cysts were
infected, besides clinical symptoms aggravation, it can speed up cysts growing
rate and damage renal function further. Common infections include upper
respiratory tract infection, urinary tract infection, gastrointestinal
infection, skin infection, trauma infection and apparatus infection, etc.
Secondly, toxin can damage various cellular organic tissues, resulting in
disease happening or even life threatening. Besides, toxin is also one of the
main reasons of gene mutation and congenital dysplasia. Some common toxins
include agricultural chemicals, some chemical agents, radiation as well as
pollution and so on. In addition, some medicines are nephrotoxic. These
medicines can cause renal injury if they are used improperly.
Polycystic Kidney Disease is the interaction of congenital and acquired
factors. We can only control acquired factors actively because we can not change
congenital factors. If you need more information about this, you can email to firstname.lastname@example.org or consult us online.