Proteinuria is one of the classical symptoms of kidney disease. But for the patients of Polycystic Kidney Disease (PKD), proteinuria is not that common. And even if the Polycystic Kidney Disease paitents have proteinuria, the amount of protein is not very much. However, the amount of the leaked protein can’t reflect the severity of disease accurately.
Patient of slight chronic kidney disease have small amount of protein, while
it doesn’t mean the slight renal damage. likewise, large amount of urine protein
doesn’t exactly mean the severe renal damage. For example, for patients with
minimal change nephritis or mild mesangial proliferative glomerulonphritis, the
pathology change of the kidneys is slight, while the urine protein amount can be
several gγrams to more than ten grams.
Generally speaking, urine protein can be divided in to selective proteinuria
and non-selective proteinuria. Selective proteinuria means that the
electrophoresis of the protein is characterized by the micro-molecular protein,
such as albumin, α1globulin, transferrin and γ globulin.
For patients of minimal change nephritis or mild mesangial proliferative
glomerulonphritis and parts of patients with mesangial proliferative
glomerulonphritis and focal stage sclerosis nephritis, their proteinuria usually
is selective proteinuria, which means the damage to the glomerulus filtration
membrane is relatively slight.
For the non-selective proteinuria, it is featured by both micro-molecular
protein and macro-molecular protein, which means the damage to the glomerulus
filtration membrane is severe.
So the patients wonder whether they can recover if the proteinuria is very
The experts remain that the amount of the urine protein can’t reflect the
damage level of the kidneys exactly, and sometimes they aren’t in proportion to
each other. So the treatment effects are determined by the types and condition
of renal damage and the renal function.
Besides, the treatment effects are also related to whether the patients can
cooperate with doctor well, whether prevent from the relapse factors(such as
cold, tiredness, infection and so on) well, whether they can insist on treatment
and prevent from the medicines with renal toxicity.