After many years of clinical practices and scientific research, Shijiazhuang
Kidney Disease Hospital has developed Micro-Chinese Medicine Osmotherapy to
treat Polycystic Kidney Disease. This treatment has improved the therapeutic
effect of Traditional Chinese Medicine by using micronized Chinese Medicine.
Generally speaking, Micro-Chinese Medicine can block Renal Fibrosis and
control cysts growing of PKD from the following methods:
Firstly, Micro-Chinese Medicine Osmotherapy can block Renal Fibrosis and
inhibit Extracellular Matrix (ECM) synthesis. When cysts of PKD grow bigger,
they compress not only functional nephron but also renal artery at all levels.
Once renal blood vessel is compressed, renal ischemia and anoxia appear which
can aggravate injury of endothelial cells of renal capillary. These injured
cells can attract blood inflammatory cells filtration, secreting a series of
nephrotoxic cellular factors. This can speed up mechanocyte in renal
interstitium turning into myofibroblast, secreting ECM which is difficult to de
degraded, which can start the process of Renal Fibrosis. And the mechanism of
micronized Chinese Medicine is to block Renal Fibrosis of PKD.
Secondly, active substances of Chinese Medicine have the function of
inhibiting proliferation of cyst epithelial cells and reducing cyst fluid
secretion. Growing cysts compress nephron progressively, speed up Renal Fibrosis
further. During this process, renal fibrous and cystic factors are secreted
continuously. Among nephrotoxic growth factors, epidermal growth factor (EGF),
transforming growth factorβ(TGF-β) and insulin-like growth factor (IGF) can
stimulate proliferation of epithelial cells of cyst wall and increase cyst fluid
secretion.
After entering into kidney lesions, micronized Chinese Medicine can inhibit
proliferation of epithelial cells of cyst wall and reduce cyst fluid secretion.
Active substances of Chinese Medicine can get into cells of cyst internal wall
directly, inhibit and prevent the combination of nephrotoxic growth factors and
related acceptor which can activate tyrosine kinase. By this way, this treatment
blocks the proliferation of epithelial cells of internal cyst wall caused by
tyrosine kinase activity. Besides, it inhibits the secretion of epithelial cells
at the same time. For this reason, micronized Chinese Medicine can be taken as
an inhibitor of tyrosine kinase to prevent epithelial cells of cyst wall
proliferating and reduce cyst fluid secretion.