Besides hereditary factors, other factors can also cause Polycystic Kidney Disease. It should be remembered that Polycystic Kidney Disease is the result of interaction of both internal factors and external factors. As for Adult Polycystic Kidney Disease, the internal factor is congenital genetic information which refers to cystic gene on the 16th chromosome; external factors of Adult Polycystic Kidney Disease include each factor that can cause abnormal change to organic internal environment. These factors include infections, nephrotoxic material and medicine, mood, tiredness and diet, etc. Under repeated action of external factors, cystic gene change metabolism of tubular epithelial cells firstly, producing growth factors and promoting cell proliferation. Then tubular obstruction and liquid retention happen, which leads to cysts formation. Besides, cystic gene can also change the condition of basement membrane and tubular wall as well as affect the communication between Na-K-ATPase and ion, which can increase cyst fluid secretion. In addition, epithelial cells apoptosis or obstruction caused by external factors directly can also promote cysts formation.
Without repeated action of external factors, internal factors will also not
change. This is also the reason why hereditary cyst gene develops into cysts
after many years with different developing speed to each other. For this reason,
patients who are suffering from Polycystic Kidney Disease should pay high
attention on daily diet and care in order to delay or prevent Polycystic Kidney